Scientist - Chemical Epigenetics

SRG are currently recruiting for a Scientist in Chemical Epigenetics to work with an exciting high-growth biotech, whose technology is set to have a major impact on personalised medicine.
This is a fantastic opportunity to work with an emerging biotech presenting a very real possibility of life-changing science. This is a rare chance to participate in developing a disruptive technology in one of the most exciting areas of Life Science and to make a substantial impact on Human Health.

Role / Description

You will be spending a significant portion of your time in the lab, where you will design, develop and commercialise ground-breaking epigenetic analysis chemistries in a fast-paced product development environment. This is a wide ranging role with real potential to have an early impact on the business.

Some of the main responsibilities are included below.

  • Optimise formulations, methods and workflows in order to achieve commercial levels of performance, stability, robustness and ease-of-use.
  • Adapt and optimise existing chemistries for epigenetic analysis of DNA and create improved methods that significantly extend capabilities.
  • Identify and source new active chemicals, additives or formulations that enable improved assay performance, stability, robustness or other desirable characteristics.
  • Characterise chemicals, reactions, reagents and methods using a variety of analytical tools in order to identify and control critical parameters.
  • Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate.
  • Develop and document lab-scale processes for the formulation and QC of critical reagents to enable scalable manufacturing processes.
  • Support the transfer of new processes and products to manufacturing.

Key Skills & Experience

  • PhD in Chemistry/Biochemistry/Molecular Biology/Genetics or similar discipline, with postdoctoral experience.
  • A background in chemistry coupled with experience of genetic analysis technologies will be particularly advantageous.
  • You will have strong skills in Chemical Biology/Molecular Biology/Biochemistry techniques,
  • Experience with NGS/DNA Sequencing/Genetic Analysis Chemistries, and good knowledge of modern analytical methods (eg, HPLC, Mass Spec and NMR).

Other key skills include:

  • Experience with NGS/DNA Sequencing/Genetic Analysis Chemistries.
  • Strong theoretical and practical chemistry skills, especially as applied to DNA.
  • Previous Industrial experience with DNA sequencing technologies or in the chemistry/biotechnology Industry.
  • Extensive knowledge of DNA/RNA modifications and chemical methods used to analyse them.
  • Experience with the extraction, purification and analysis of cell-free DNA, and experience with single-cell sequencing methods and data analysis.
  • Experience of developing life science products or technologies in a commercial environment.

Please contact Marcus to discuss further: 0121 726 9711 -